Idiopathic pulmonary fibrosis: Medical research

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This video was made in collaboration with a support group of patients diagnosed with idiopathic pulmonary fibrosis (IPF). Currently, there is a lot of research in this field and ongoing investigations for finding a cure or potential treatments for IPF. This video explains the research process, pre-clinical and clinical phases required to obtain approval for use in patients. The video starts with an overview of IPF and focuses on the overall clinical trial process by using an IPF drug known as Pirfenidone as it moves through the various stages of clinical trials. The video can also be used as a case study example of the clinical trial process. Lastly, the video introduces resources for accessing up-to-date information about various drugs and treatments that are going through the clinical trial process.

For more information about clinical trials visit the US National Library of Medicine: https://clinicaltrials.gov

Please also see previous educational videos made by McMaster Demystifying Medicine students for additional information about IPF, including clinical, patient and research perspectives:
https://healthsci.mcmaster.ca/demystifying-medicine/video-library/ipf

This video was made by the McMaster Demystifying Medicine students Pouriya Sadeghighazichaki, Tania Namrud, Albert Huynh and Nazilm Bilgin.

Special thanks to the Hamilton support group for IPF that provided feedback in order to improve the content of this video.

Copyright McMaster University 2020

References:

Akhondzadeh, S. (n.d.). The Importance of Clinical Trials in Drug Development. Avicenna Journal of Medical Biotechnology, 8(4), 151. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/27920881

Kim, E. S., & Keating, G. M. (2015). Pirfenidone: A Review of Its Use in Idiopathic Pulmonary Fibrosis. Drugs, 75(2), 219–230. https://doi.org/10.1007/s40265-015-0350-9

King, T. E., Pardo, A., & Selman, M. (2011). Idiopathic pulmonary fibrosis. The Lancet, 378(9807), 1949–1961. https://doi.org/10.1016/S0140-6736(11)60052-4

Umscheid, C. A., Margolis, D. J., & Grossman, C. E. (2011). Key Concepts of Clinical Trials: A Narrative Review. Postgraduate Medicine, 123(5), 194–204. https://doi.org/10.3810/pgm.2011.09.2475

Xaubet, A., Serrano-Mollar, A., & Ancochea, J. (2014). Pirfenidone for the treatment of idiopathic pulmonary fibrosis. Expert Opinion on Pharmacotherapy, 15(2), 275–281. https://doi.org/10.1517/14656566.2014.867328

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