Mesothelioma sign symptoms and Treatment for Mesothelioma
this explain mesothelioma stages, mesothelioma types, mesothelioma symptoms, and mesothelioma diagnosis. Most importantly mesothelioma treatments are discussed. This is the mesothelioma(asbestos cancer) video in a new series aimed at providing the most comprehensive information possible to patients and their families. Other videos in the series may contain information on how people receive financial compensation for medical bills, pain management techniques, hospitals – doctors, and helpful guides on what to do after diagnosis. We sincerely hope you learn something from our mesothelioma videos and thank you for watching.
Mesothelioma | sign and symptoms for Mesothelioma may not appear until 20 to 50 years (or more) after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space, or pleural effusion, are often symptoms of pleural mesothelioma.
Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites, which is a buildup of fluid in the abdominal cavity. Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.
These symptoms may be caused by mesothelioma or by other, less serious conditions.
Mesothelioma that affects the pleura, can cause these signs and symptoms:
Chest wall pain.
Pleural effusion, or fluid surrounding the lung.
Shortness of breath.
Fatigue or anemia.
Wheezing, hoarseness, or cough.
Blood in the sputum, fluid, coughed up, or hemoptysis.
In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread to other parts of the body.
Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:
Ascites, or an abnormal buildup of fluid in the abdomen.
A mass in the abdomen.
Problems with bowel function.
In severe cases of the disease, the following signs and symptoms may be present:
Blood clots in the veins, which may cause thrombophlebitis.
Disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs.
Jaundice, or yellowing of the eyes and skin.
Low blood sugar level.
Pulmonary emboli, or blood clots in the arteries of the lungs.
A mesothelioma does not usually spread to the bone, brain, or adrenal glands. Pleural tumors are usually found only on one side of the lungs.
Treatment for mesothelioma
Chemotherapy is the mainstay of treatment, with surgery
only included in multimodality treatment if there is localized disease that can be surgically resected. The optimal surgical approach is still under debate. For localized disease,surgical options include pleurectomy and decortication (surgical stripping of the pleura and pericardium from apex of the lung to diaphragm) or extrapleural pneumonectomy(a radical surgical procedure involving removal of the ipsilateral
lung, parietal and visceral pleura, pericardium, and
most of the hemidiaphragm). Limited nonrandomized data
have shown that a trimodality approach for localized disease
with extrapleural pneumonectomy, adjuvant radiation,
and (neoadjuvant or adjuvant) chemotherapy can prolong
survival in highly selected patients. However, the benefit of
extrapleural pneumonectomy has been brought into question
with the results of the Mesothelioma and Radical Surgery
(MARS) trial. This small randomized study, comparing
extrapleural pneumonectomy with no extrapleural pneumonectomy after induction chemotherapy in 50 patients, showed that extrapleural pneumonectomy offers no survival benefit and may cause more harm. In advanced disease, palliative chemotherapy with cisplatin and pemetrexed can achieve response rates of 30–40%, extend median overall survival to 12 months, and improve quality of life. Other alternative chemotherapy regimens include gemcitabine,
anthracyclines, or vinorelbine. Drainage of pleural effusions, pleurodesis, radiation therapy, and even surgical resection may offer palliative benefit in some patients.
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